The accelerated pace of biological research and the advent of genomics have resulted in the prodigious accumulation of data about genes and their relationship to biological terms such as "cell cycle".  This information is scattered among millions of different records in sources such as Medline.  In order to rapidly and comprehensively summarize the biological literature, we used an automated approach to assemble MeSH-gene co-citation matrices from the titles, abstracts and MESH indexes of over 11 million Medline records and normalized these MeSH-gene relationships into rank order.  The resulting database, termed BioGene, can generate lists of genes for use in high-throughput screening experiments, can create MeSH-specific micro-arrays, and can sort the results of gene profiling data.  

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